https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45256 1.4 million individuals, we show that FROH is significantly associated (p < 0.0005) with apparently deleterious changes in 32 out of 100 traits analysed. These changes are associated with runs of homozygosity (ROH), but not with common variant homozygosity, suggesting that genetic variants associated with inbreeding depression are predominantly rare. The effect on fertility is striking: FROH equivalent to the offspring of first cousins is associated with a 55% decrease [95% CI 44–66%] in the odds of having children. Finally, the effects of FROH are confirmed within full-sibling pairs, where the variation in FROH is independent of all environmental confounding.]]> Wed 26 Oct 2022 20:06:39 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55187 Wed 24 Apr 2024 10:02:08 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43989 Wed 13 Mar 2024 19:11:12 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52436 Wed 11 Oct 2023 14:54:40 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22902 Wed 11 Apr 2018 11:55:45 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50431 Tue 25 Jul 2023 19:01:27 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50411 Tue 25 Jul 2023 17:30:33 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48599 Tue 04 Apr 2023 19:22:25 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53399 Thu 23 Nov 2023 13:44:14 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53055 Fri 17 Nov 2023 11:47:02 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47334 Fri 13 Jan 2023 11:55:34 AEDT ]]>